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Published on: April 21, 2012
Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report
Olga Zerpa1, Belkys Blanco, Carmen Kannee
1Institute of Biomedicine, Ministry of Health and Social Development and Central University of Venezuela, Caracas, Venezuela. ozerpa@telcel.net.ve
Background:
A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine.
Methods:
The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently.
Results:
Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed.
Conclusions:
The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.
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