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Left ventricular diastolic dysfunction in obese women.
Idrus Alwi1, S Harun, Satrio Sukmono
1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo General Hospital, Jakarta.
Acta Medica Indonesiana
|June 27, 2006
Summary
Obesity directly impacts diastolic function in women, increasing mitral filling velocity and decreasing pulmonary diastolic velocity. Subclinical diastolic dysfunction is more common in obese individuals, indicating a need for further cardiovascular health monitoring.
Area of Science:
- Cardiology
- Obesity Research
- Echocardiography
Background:
- Obesity is a growing public health concern associated with various cardiovascular complications.
- Left ventricular diastolic function plays a crucial role in maintaining cardiac output and is sensitive to metabolic changes.
Purpose of the Study:
- To investigate the direct impact of obesity on echocardiographic measures of diastolic left ventricular function.
- To identify specific echocardiographic indices affected by obesity in women.
Main Methods:
- A comparative study involving 44 obese women (BMI ≥ 25 kg/m²) and 45 normal-weight women.
- Echocardiographic assessment of diastolic function parameters, with dysfunction defined as ≥ 2 standard deviations from the normal group.
- Exclusion of participants with other pathological conditions to isolate the effect of obesity.
Main Results:
- Obese women exhibited significantly increased maximum velocity of active mitral filling (A) and decreased pulmonary diastolic velocity (p<0.01).
- Other diastolic variables remained unchanged between groups.
- A trend towards higher prevalence of subclinical diastolic dysfunction in obese subjects (20.5%) compared to normal-weight subjects (8.9%) was observed, though not statistically significant (p=0.11).
Conclusions:
- Obesity is directly associated with alterations in left ventricular diastolic function.
- Subclinical diastolic dysfunction is more prevalent in obese women, highlighting potential cardiovascular risks.