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Endometriosis and possible malignant transformation.

M Gojnic¹, V Dugalic, V Jeremic

¹Institute of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade University, Serbia and Montenegro.

European Journal of Gynaecological Oncology

|June 28, 2006

Summary

Endometriosis is a common cause of infertility, found in 453 out of 683 laparoscopies. Cancerous ovarian changes were rare, diagnosed in only 8% of cases during this infertility study.

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Area of Science:

Gynecology
Reproductive Medicine
Surgical Oncology

Background:

Infertility affects a significant portion of the population.
Endometriosis is a recognized contributor to female infertility.
Laparoscopy is a key diagnostic and therapeutic tool for gynecological conditions.

Purpose of the Study:

To investigate the prevalence of endometriosis as a cause of infertility.
To assess the incidence of ovarian cancer in patients undergoing laparoscopy for infertility.
To document surgical interventions for endometriosis and related conditions.

Main Methods:

Retrospective analysis of 683 laparoscopy cases over three years in Belgrade hospitals.
Surgical removal of endometrial foci and genital/peritoneal abnormalities using laser.
Histological examination of tissue samples.
Documentation of diagnosed ovarian pathologies and subsequent treatments.

Main Results:

Endometriosis was diagnosed in 453 out of 683 laparoscopy cases (approximately 66%).
Ovarian cancer was diagnosed in only 8% of cases with confirmed endometriosis.
Four out of 36 patients with established diagnoses underwent hysterectomy and bilateral salpingo-oophorectomy.

Conclusions:

Endometriosis is a highly prevalent condition associated with infertility in the studied population.
Malignant ovarian changes are infrequent in women undergoing laparoscopy for infertility due to endometriosis.
Surgical management, including laser ablation and, in select cases, hysterectomy with bilateral salpingo-oophorectomy, is employed.