Related Experiment Video
Updated: Dec 10, 2025

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
Published on: May 4, 2020
Changes of Hippocampal Noradrenergic Capacity in Stress Condition
L Gavrilović1, N Popović1, V Stojiljković1
1"Vinča" Institute of Nuclear Sciences, National Institute of the Republic of Serbia, Laboratory of Molecular Biology and Endocrinology, University of Belgrade, Belgrade, Serbia.
Abstract:
This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition.
Related Concept Videos
Hypothalamic-Pituitary Axis
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Introduction to Stress and Lifestyle
Psychological Responses to Stress
Role of Hippocampus in Memory

