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Updated: Aug 7, 2026

Murine Mesenteric Lymphadenectomy for Selective Disruption of Lymphatic Communication with Region-Specific Gut
Published on: December 30, 2025
Lymphadenectomy in metastasectomy
Alberto Dominguez-Ventura1, Francis C Nichols
1Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Abstract:
Although surgery for pulmonary metastases does not benefit a significant number of patients, PM should continue to be offered to patients whose primary tumor is controlled and who have acceptable operative risks. For a survival benefit to be achieved, all extrathoracic and pulmonary metastases must be amenable to complete surgical resection. We have shown that the presence of metastatically involved lymph nodes discovered during PM adversely effects survival in patients undergoing curative PM. We therefore continue to recommend complete mediastinal lymphadenectomy at the time of PM to define the patient's prognosis and perhaps to guide adjuvant therapy.

