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Updated: Aug 7, 2026
Isolated Lung Perfusion System in the Rabbit Model
Published on: July 15, 2021
Isolated lung perfusion for pulmonary metastases
Jeroen M H Hendriks1, Bart P Van Putte, Marco Grootenboers
1Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Wilrijkstraat 10 B-2650, Edegem, Belgium. jeroen.hendriks@uza.be
Abstract:
Isolated lung perfusion is an experimental surgical technique evaluated for the delivery of high-dose chemotherapy to improve 5-year survival after pulmonary metastasectomy. Extensive experimental work in animal models has demonstrated superior pharmacokinetics and efficacy compared with systemic therapy. Phase I clinical trials of isolated lung perfusion found a maximum tolerated dose**** of TNF-alpha, doxorubicin, cisplatin, and melphalan, whereas the combination of isolated lung perfusion with a complete metastasectomy was feasible. The combination of isolated lung perfusion and regional lung perfusion techniques needs further investigation.
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