Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inducible proteopathies.

Lary C Walker1, Harry Levine, Mark P Mattson

  • 1Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA. lary.walker@emory.edu

Trends in Neurosciences
|June 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subconjunctival Triamcinolone Acetonide Injection Compared with Dexamethasone Ophthalmic Insert for Inflammation Prophylaxis After Cataract Surgery: A Comparative Clinical Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Management of Post-Operative Inflammation After Cataract Surgery with Intracanalicular Dexamethasone Implant and Topical Ketorolac.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Perspectives on eye care access and telemedicine-based glaucoma screening among Latine individuals with limited English proficiency.

AJO international·2025
Same author

Hardware-efficient quantum error correction via concatenated bosonic qubits.

Nature·2025
Same author

The prion principle and Alzheimer's disease.

Science (New York, N.Y.)·2024
Same author

Dexamethasone Intracanalicular Insert versus Standard Topical Steroids for the Prophylaxis of Inflammation after Cataract Surgery.

American journal of ophthalmology·2024
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

Aberrant protein polymerization causes proteopathies like Alzheimer's and Parkinson's. Mechanistic insights into protein misfolding offer new therapeutic avenues for these degenerative diseases.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pathology

Background:

  • Degenerative diseases, or proteopathies, involve abnormal protein polymerization and accumulation.
  • Examples include Alzheimer's, Parkinson's, Huntington's diseases, prion diseases, and systemic amyloidoses.

Purpose of the Study:

  • To review mechanistic similarities among various proteopathies.
  • To explore opportunities for understanding in vivo protein misfolding and assembly.
  • To discuss integrated therapeutic approaches for degenerative proteopathies.

Main Methods:

  • Literature review of protein polymerization and disease mechanisms.
  • Analysis of transmissible and non-transmissible proteopathy induction.
  • Comparative study of molecular templating in disease.

Related Experiment Videos

Main Results:

  • Prion diseases are transmissible via altered prion protein conformations.
  • Evidence suggests some amyloidoses can be induced by molecular templates.
  • Shared mechanisms in protein misfolding offer therapeutic targets.

Conclusions:

  • Understanding shared mechanisms in proteopathies is crucial.
  • Developing integrated therapies for diverse degenerative diseases is feasible.
  • Further research into protein misfolding induction can advance treatment.