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Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Related Experiment Video

Updated: May 11, 2026

Collection of Serum- and Feeder-free Mouse Embryonic Stem Cell-conditioned Medium for a Cell-free Approach
09:32

Collection of Serum- and Feeder-free Mouse Embryonic Stem Cell-conditioned Medium for a Cell-free Approach

Published on: January 8, 2017

Stem cells, ageing and the quest for immortality.

Thomas A Rando1

  • 1Geriatric Research, Education and Clinical Center (GRECC), VA Palo Alto Health Care System, Stanford, California 94305, USA. rando@stanford.edu

Nature
|July 1, 2006
PubMed
Summary

Adult stem cells decline with age, impacting tissue repair. Understanding if stem cells intrinsically age or if the tissue environment impairs them is key for regenerative medicine therapies.

Area of Science:

  • Stem cell biology
  • Aging research
  • Regenerative medicine

Background:

  • Adult stem cells are crucial for tissue homeostasis and repair across mammalian tissues.
  • Tissue regenerative potential significantly decreases with advancing age.
  • The precise causes of age-related regenerative decline remain incompletely understood.

Purpose of the Study:

  • To investigate the contributions of intrinsic stem cell aging versus extrinsic aged tissue environment to the decline in regenerative capacity.
  • To differentiate between stem cell autonomous aging and stem cell non-autonomous aging mechanisms.
  • To inform the development of effective regenerative medicine strategies.

Main Methods:

  • Comparative analysis of stem cell function in young versus aged tissue environments.

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Last Updated: May 11, 2026

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  • Assessment of intrinsic stem cell aging markers.
  • Evaluation of tissue microenvironment factors affecting stem cell behavior.

    • Main Results:

    • Preliminary findings suggest a complex interplay between intrinsic stem cell aging and the aged tissue milieu.
    • Specific molecular pathways involved in age-related stem cell dysfunction are being identified.
    • The aged tissue environment demonstrably impairs stem cell function.

    Conclusions:

    • Distinguishing between intrinsic stem cell aging and environmental influences is critical for understanding age-related tissue dysfunction.
    • Targeting either the stem cells themselves or the aged tissue environment may offer therapeutic avenues.
    • This research is vital for advancing regenerative medicine applications for age-related diseases and injuries.