Dissecting CXCR5+ T cell populations--on the quest for a better understanding of B cell help during T dependent antibody responses
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Updated: Aug 7, 2026

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
Published on: April 26, 2024
1Div. of Rheumatology and Clinical Immunology, University Clinic Freiburg, Hugstetterstrasse 55, D-79106 Freiburg, Germany. klaus.warnatz@uniklinik-freiburg.de
Abstract:
High affinity antibody responses against protein antigens critically depend on T cell help during the germinal center reaction. So called follicular helper T cells (T(FH)), present in the germinal centers of human tonsils, have been characterised by the expression of CXCR5; however, only subgroups of the heterogeneous CXCR5 T cell population strongly support antibody production. A paper in this issue of the European Journal of Immunology demonstrates that high expression of the inducible co-stimulator (ICOS) molecule, rather than CD57, correlates with the follicular helper function. This result represents another step towards a better understanding of the complexity of the different T cell subpopulations participating in the germinal center reaction.
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