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Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess
Published on: March 15, 2024
Questions about the use of antibiotics in acute pancreatitis
Tercio De Campos1, Jose Cesar Assef, Samir Rasslan
1Emergency Surgery Unit, Santa Casa School of Medical Sciences, São Paulo, Brazil. tercio@uol.com.br
Background And Objective:
The use of antibiotics in acute pancreatitis despite recent clinical trials remains controversial. The aim of this study is to review the latest clinical trials and guidelines about antibiotics in acute pancreatitis and determine its proper use.
Methods:
Through a Medline search, we selected and analyzed pertinent randomized clinical trials and guidelines that evaluated the use of antibiotics in acute pancreatitis. We answered the most frequent questions about this topic.
Results And Conclusion:
Based on these clinical trials and guidelines, we conclude that the best treatment currently is the use of antibiotics in patients with severe acute pancreatitis with more than 30% of pancreatic necrosis. The best option for the treatment is Imipenem 3 x 500 mg/day i.v. for 14 days. Alternatively, Ciprofloxacin 2 x 400 mg/day i.v. associated with Metronidazole 3 x 500 mg for 14 days can also be considered as an option.
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Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis II: Pathophysiology
Acute Pyelonephritis II: Diagnostic Studies and Management
Chronic Pancreatitis II: Collaborative Care
Assessment: