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Updated: Aug 7, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
[Cancer-protecting genes (tumor-suppressor genes)]
1Københavns Universitet, Institut for Medicinsk Biokemi & Genetik, Panum Instituttet, DK-2200 København N. jolsen@imbg.ku.dk
Abstract:
Tumor-suppressor genes protect against the development of cancer. The prototypical tumor-suppressor gene is one that controls G1 to S progression in the cell cycle. However, genes that are involved in DNA-repair or induction of apoptosis also protect against the development of cancer. More generally speaking, tumor-suppressor genes either prevent the introduction of somatic mutations or the amplification of the population of somatic cells carrying mutations. Well-known tumor-suppressor genes that also give rise to inherited cancer disorders are described in the review.
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