Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Checkpoints in memory B-cell evolution.

Louise J McHeyzer-Williams1, Laurent P Malherbe, Michael G McHeyzer-Williams

  • 1The Scripps Research Institute, La Jolla, CA 92037, USA.

Immunological Reviews
|July 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid.

Frontiers in immunology·2025
Same author

Essential role of pre-existing humoral immunity in TLR9-mediated type I IFN response to recombinant AAV vectors in human whole blood.

Frontiers in immunology·2024
Same author

The HLA class I immunopeptidomes of AAV capsid proteins.

Frontiers in immunology·2023
Same author

The HLA class-II immunopeptidomes of AAV capsids proteins.

Frontiers in immunology·2023
Same author

Evolution of antigen-specific follicular helper T cell transcription from effector function to memory.

Science immunology·2022
Same author

Isotype-specific plasma cells express divergent transcriptional programs.

Proceedings of the National Academy of Sciences of the United States of America·2022

This study reviews the four phases of B-cell memory evolution, focusing on T-helper cell regulation and developmental checkpoints. Understanding these stages is crucial for effective immune memory consolidation.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • B-cell memory evolution involves sequential phases regulated by antigen-specific T-helper (Th) cells.
  • Developmental checkpoints controlling cell fate in these phases are not fully understood.
  • Immune stimulus type influences checkpoint composition and molecular attributes.

Purpose of the Study:

  • To review recent advances in understanding memory B-cell evolution.
  • To emphasize the regulatory checkpoints governing lymphocyte fate.
  • To elucidate the mechanisms of high-affinity B-cell memory consolidation.

Main Methods:

  • Review of recent scientific literature on B-cell memory.
  • Analysis of regulatory mechanisms involving T-helper cells.
  • Examination of germinal center reactions and antigen presentation.

Related Experiment Videos

Main Results:

  • Identified four sequential phases in B-cell memory development.
  • Highlighted the critical role of cognate T-helper cell regulation.
  • Described how immune stimuli initiate effector mechanisms and memory consolidation.

Conclusions:

  • Immune memory is established and consolidated through specific developmental checkpoints.
  • Antigen re-challenge rapidly activates and strengthens both T-helper and B-cell memory.
  • Further research into checkpoint regulation is vital for understanding lymphocyte fate.