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Updated: Aug 7, 2026
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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Prognosis after sentinel node biopsy in malignant melanoma]
Jørgen Lock-Andersen1, Janne Horn, Helle Sjøstrand
1Plastikkirurgisk Afdeling, Roskilde Amts Sygehus Roskilde, DK-4000 Roskilde. j.lock-andersen@dadlnet.dk
Ugeskrift for Laeger
|July 11, 2006
Summary
Sentinel node biopsy (SNB) accurately identifies malignant melanoma patients at high risk for recurrence. SNB status is a crucial prognostic factor, guiding careful follow-up for positive cases to improve survival outcomes.
Area of Science:
- Oncology
- Surgical Pathology
Context:
- Sentinel node biopsy (SNB) is a standard procedure for staging cutaneous malignant melanoma (MM).
- Early detection of lymph node metastasis is crucial for patient prognosis and treatment planning.
Purpose:
- To evaluate the efficacy of SNB in detecting subclinical lymph node metastasis in MM patients.
- To assess the prognostic value of SNB status on recurrence rates and survival.
Summary:
- SNB identified regional lymph node metastasis in 32% of MM patients.
- SN-positive patients had significantly higher recurrence rates (23% vs 7%) and mortality (18% vs 3%) compared to SN-negative patients.
- Extracapsular extension, multiple metastatic nodes, and positive formal dissection were risk factors for recurrence.
Impact:
- SNB status is a powerful predictor of MM recurrence and mortality.
- Identifying high-risk patients allows for targeted surveillance and management.
- This study reinforces the importance of SNB in the management of cutaneous malignant melanoma.
