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Published on: June 20, 2018
Sex differences in outcomes of sinus surgery
Sabrina Mendolia-Loffredo1, Purushottam W Laud, Rodney Sparapani
1Department of Otolaryngology, MCW Center for Patient Care and Outcomes Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
The Laryngoscope
|July 11, 2006
Summary
While objective measures of chronic rhinosinusitis (CRS) after endoscopic sinus surgery (ESS) show no sex differences, females report worse quality of life (QOL). This QOL difference is linked to higher rates of acetylsalicylic acid (ASA) intolerance and depression in females.
Area of Science:
- Otolaryngology
- Surgical Outcomes
- Patient-Reported Outcomes
Background:
- Sex influences disease outcomes across various medical conditions.
- Chronic rhinosinusitis (CRS) is a prevalent condition affecting quality of life.
- Endoscopic sinus surgery (ESS) is a common treatment for CRS.
Purpose of the Study:
- To investigate the impact of sex on outcomes following endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS).
- To determine if sex is a predictor of surgical success in CRS patients.
Main Methods:
- Prospective evaluation of 44 males and 73 females undergoing ESS for CRS.
- Assessment included computed tomography (CT), endoscopy, and quality of life (QOL) measures.
- Univariate and multiple logistic regression analyses were used to assess sex as a predictor.
Main Results:
- No significant sex differences were observed in CT scans or endoscopic findings.
- Females reported worse disease-specific QOL scores both pre- and postoperatively.
- Sex did not predict QOL improvement or endoscopic outcomes; however, female sex was associated with ASA intolerance and depression.
Conclusions:
- Despite similar objective surgical outcomes, females with CRS experience poorer QOL post-ESS.
- Sex-specific differences in QOL are attributed to higher prevalence of acetylsalicylic acid (ASA) intolerance and depression in females.
- These comorbidities, rather than surgical outcomes, may explain the observed sex disparities in QOL.
