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[The prognostic role of gamma-glutamyltransferase for cardiovascular events]
Michele Emdin1, Alfonso Pompella, Claudio Passino
1Unità Operativa Medicina Cardiovascolare, Istituto di Fisiologia Clinica, CNR, Pisa. emdin@ifc.cnr.it
Abstract:
Serum gamma-glutamyltransferasis activity is a low-cost, highly sensitive laboratory test. Though it is currently considered as an index of hepato-biliary dysfunction and alcohol abuse, recent epidemiological and pathologic studies have proposed its independent role in the pathogenesis and clinical evolution of cardiovascular diseases brought by atherosclerosis, associated with a gamma-glutamyltransferase-linked prooxidant effect of glutathione catabolism within the plaque.
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