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The right tools at the right time.

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Asthma is often underdiagnosed and undertreated, with many patients not achieving control despite available treatments. Early intervention with inhaled corticosteroids (ICS) is crucial for managing persistent asthma and improving long-term outcomes.

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Area of Science:

  • Pulmonary Medicine
  • Allergy and Immunology
  • Pharmacology

Background:

  • Asthma affects 300 million globally, frequently underdiagnosed and undertreated.
  • Current treatment often involves excessive use of relief medications and underuse of inhaled corticosteroids (ICS).
  • Patient-related factors like anxiety about side effects and perceived control contribute to treatment gaps.

Purpose of the Study:

  • To highlight the discrepancies between asthma treatment guidelines and clinical practice.
  • To emphasize the importance of early and optimal anti-inflammatory therapy for persistent asthma.
  • To review the role of inhaled corticosteroids (ICS) and add-on therapies in asthma management.

Main Methods:

  • Review of current asthma prevalence and treatment patterns.
  • Analysis of the efficacy and safety of inhaled corticosteroids (ICS).
  • Evaluation of add-on therapies and combination inhalers for moderate-to-severe persistent asthma.

Main Results:

  • Inhaled corticosteroids (ICS) rapidly improve symptoms and lung function, and reduce exacerbations and mortality.
  • While ICS monotherapy controls persistent asthma for many, add-on therapy with long-acting beta2-agonists is effective for most moderate-to-severe cases.
  • Fixed combination inhalers offer convenience but carry risks of overuse.

Conclusions:

  • Inhaled corticosteroids (ICS) are the foundation of persistent asthma treatment across all severities in adults and children.
  • Early therapeutic intervention with ICS is recommended for optimal long-term asthma control and outcomes.
  • Addressing patient-related barriers is essential for improving asthma management and adherence to ICS therapy.