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Oxidative stress in hepatitis C infected end-stage renal disease subjects

Mehmet Horoz1, Cengiz Bolukbas, Filiz F Bolukbas

  • 1Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey. mehmethoroz@yahoo.com

BMC Infectious Diseases
|July 18, 2006
PubMed

Insights

Hemodialysis patients experience increased oxidative stress, regardless of hepatitis C infection status. Hepatitis C does not appear to further elevate oxidative stress in these individuals, possibly due to dialysis effects.

Area of Science:

  • Nephrology
  • Hepatology
  • Biochemistry

Background:

  • Uremia and hepatitis C infection are linked to elevated oxidative stress.
  • The study investigates the impact of hepatitis C on oxidative stress in hemodialysis patients.

Purpose of the Study:

  • To determine if hepatitis C infection exacerbates oxidative stress in hemodialysis subjects.
  • To compare oxidative stress markers between hepatitis C positive and negative hemodialysis patients and healthy controls.

Main Methods:

  • Included 16 hepatitis C (+) hemodialysis subjects, 24 hepatitis C (-) hemodialysis subjects, and 24 healthy controls.
  • Measured total antioxidant capacity, total peroxide level, and oxidative stress index in all participants.

Main Results:

  • Controls exhibited higher total antioxidant capacity and lower peroxide levels/oxidative stress index compared to both hemodialysis groups (p < 0.05/3).
  • Hepatitis C (-) hemodialysis subjects showed higher antioxidant capacity than hepatitis C (+) subjects (p < 0.05/3).
  • Peroxide levels and oxidative stress index were similar between hemodialysis groups (p > 0.05/3).

Conclusions:

  • Hemodialysis subjects, with or without hepatitis C, have increased oxidative stress.
  • Hepatitis C infection does not significantly increase oxidative stress in hemodialysis patients.
  • Dialysis treatment might offer a protective effect against further oxidative stress in hepatitis C infected hemodialysis patients.
Abstract

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