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Related Experiment Videos

Chemically induced bladder cancer--a sonographic and morphologic description.

Ofrer N Gofrit1, Tatiana Birman, Anna Dinaburg

  • 1Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel. ong1000@netvision.net.il

Urology
|July 18, 2006
PubMed
Summary

Ultrasonography accurately monitors bladder cancer progression in rats. Digital measurements at necropsy precisely assess tumor burden, improving this key animal model for cancer therapy evaluation.

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Area of Science:

  • Oncology
  • Animal Models
  • Diagnostic Imaging

Background:

  • Rodent models are crucial for evaluating novel bladder cancer therapies.
  • Assessing tumor burden in living animals and at necropsy presents a significant challenge in these models.

Purpose of the Study:

  • To present simple and accurate methods for assessing tumor burden in a rat bladder cancer model.
  • To improve the utility of the N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) rat model for cancer research.

Main Methods:

  • Female Wistar rats were administered N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in drinking water for 35 weeks.
  • Tumorigenesis was periodically evaluated using ultrasonography in anesthetized animals.
  • Tumor burden at necropsy was assessed by bladder weight, digital measurement of tumor dimensions, and histological examination.

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Main Results:

  • Urothelial hyperplasia, dysplasia, and transitional cell carcinoma developed progressively from the 5th week onwards.
  • Ultrasonography allowed for the detection and measurement of tumors as small as 1 mm.
  • Digital measurement of tumor dimensions showed a poor correlation with bladder weight for small tumors (R2 = 0.33) but a good correlation for larger tumors (R2 = 0.81).

Conclusions:

  • Ultrasonography provides accurate monitoring of tumor progression in the BBN rat model.
  • Digital measurement of tumor dimensions offers a precise method for evaluating tumor burden post-mortem.