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Updated: Aug 7, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
The initial (earliest) report of polymorphous ventricular tachycardia
1Beth Israel Medical Center, University Hospital of the Albert Einstein College of Medicine, Department of Cardiology, New York, NY 10003, USA.
This historical review traces the early discoveries of polymorphic ventricular tachycardia, including initial observations in 1918 and specific forms like torsades de pointes and catecholaminergic polymorphic ventricular tachycardia.
Area of Science:
- Cardiology
- Medical History
- Electrophysiology
Background:
- Polymorphic ventricular tachycardia (PVT) is a critical cardiac arrhythmia.
- Understanding its historical context is essential for current clinical practice.
Observation:
- The earliest documented observation of PVT-like arrhythmia was by Wilson and Robinson in 1918.
- They described a tachyarrhythmia with multiple, varied extrasystoles during complete heart block.
- This predates the formal recognition of specific PVT subtypes.
Findings:
- Torsades de pointes, a specific form of PVT, was first recognized in 1966 by Dessertenes.
- Catecholaminergic polymorphic ventricular tachycardia (CPVT) was first described by Reid in 1977.
- These findings highlight a progressive understanding of PVT's diverse manifestations.
Implications:
- Early descriptions laid the groundwork for modern understanding of ventricular arrhythmias.
- Recognizing historical milestones aids in diagnosing and managing complex tachycardias.
- This historical perspective informs ongoing research into PVT mechanisms and treatments.
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