Effect of interleukin-1beta on NMDA-induced 45Ca2+ uptake by synaptosomes of rat brain cortex
L N Petrova1, V V Grigor'ev, S O Bachurin
1Laboratory of Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka.
Bulletin of Experimental Biology and Medicine
|July 20, 2006
Abstract:
The effect of interleukin-1beta on presynaptic NMDA receptors was evaluated by studying NMDA-induced 45Ca2+ uptake by synaptosomes from rat brain cortex. Interleukin-1beta inhibited 45Ca2+ uptake by synaptosomes. Our results indicate that interleukin-1beta modulates presynaptic NMDA receptors and is probably involved in the regulation of synaptic transmission in the central nervous system.


