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Updated: Jul 10, 2026
An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry
Published on: May 13, 2019
Ploidy of micronucleated thyrocytes induced by methylnitrosourea injection
A V Pavlov1, A N Gansburgskii, M A Gansburgskii
1Department of Histology, Cytology, and Embryology, Yaroslavl State Medical Academy. pavlov@hist.yma.ac.ru
Abstract:
Ploidy of thyroid parenchyma was studied in adult rats in the control and on day 9 after hemithyroidectomy; operated animals received 3 injections of N-nitroso-N-methylurea. The population of follicular thyrocytes is mainly diploid; total count of polyploid cells increased from 4.4% in the control to 8.5% in experimental rats. All thyrocytes containing micronuclei were tetraploid. No diploid micronucleated elements were detected. This suggests that genetically damaged thyrocytes divide by the mechanism of acytokinetic (polyploidizing) mitosis.
