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Updated: Aug 7, 2026

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
Published on: August 9, 2019
[Signal transduction of IL-3 in regulating hematopoietic stem cell proliferation and differentiation]
Tao Guan1, Sha-Li Wang, Ya-Ping Wang
1Department of Physiology, Chongqing University of Medical Science, Chongqing 400016, China.
Abstract:
IL-3 is also called as multi-lineage colony stimulating factor, which can positively regulate proliferation and differentiation of hematopoietic stem cell. After binding to its receptor on target cell, IL-3 can regulate hematopoietic stem cell to survive, proliferate, differentiate or to mature by transmitting growth, proliferation and differentiation signals. This paper is to summarize the signal transduction pathways of IL-3 in regulating hematopoietic stem cell proliferation and differentiation.
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