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Related Experiment Videos

Measuring free-energy difference between crystal polymorphs through eutectic melting.

Lian Yu1, Jun Huang, Karen J Jones

  • 1University of Wisconsin-Madison, School of Pharmacy, 777 Highland Avenue, Madison, Wisconsin 53705-2222, USA. lyu@pharmacy.wisc.edu

The Journal of Physical Chemistry. B
|July 21, 2006
PubMed
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A new method quantifies free-energy differences (DeltaG) between crystal polymorphs using calorimetric data. This technique aids in understanding crystal stability and controlling crystallization processes.

Area of Science:

  • Crystallography
  • Physical Chemistry
  • Materials Science

Background:

  • Understanding crystal polymorphism is crucial for material properties.
  • Measuring free-energy differences (DeltaG) between polymorphs is challenging.
  • Existing methods may fail for compounds that decompose or transform before melting.

Purpose of the Study:

  • To develop a novel method for measuring the free-energy difference (DeltaG) between crystal polymorphs.
  • To extend the applicability of DeltaG measurements to systems that undergo decomposition or transformation before melting.
  • To provide a versatile method applicable to polymorphs, racemates, and conglomerates.

Main Methods:

  • Utilizing calorimetric data from eutectic melting with common additives.

Related Experiment Videos

  • Employing different additives to determine DeltaG as a function of temperature.
  • Applying the method to various compounds, including glycine, d-mannitol, and tazofelone.

    • Main Results:

    • Successfully measured DeltaG between crystal polymorphs using the described calorimetric method.
    • Reported a new enantiotropic transition temperature of 123°C for alpha and gamma glycine.
    • Demonstrated the method's versatility with different additives, including water.

    Conclusions:

    • The developed method accurately measures free-energy differences (DeltaG) in polymorphic systems.
    • This technique is valuable for structure-stability studies and controlling crystallization.
    • The method's applicability extends to challenging systems and different enantiomeric forms.