Search research articles

Search research articles

Related Experiment Videos

Bronchodilators for bronchiolitis.

A M Gadomski¹, A L Bhasale

¹Mary Imogene Bassett Hospital, Research Institute, 1 Atwell Road, Cooperstown, NY 13326, USA. gadomski@usa.net

The Cochrane Database of Systematic Reviews

|July 21, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pet dogs and child physical activity: the role of child-dog attachment.

Pediatric obesity·2016

Same author

Impact of a rural domestic violence prevention campaign.

The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association·2002

Same author

Changes in health care providers' knowledge, attitudes, beliefs, and behaviors regarding domestic violence, following a multifaceted intervention.

Academic medicine : journal of the Association of American Medical Colleges·2001

Same author

Bronchodilators for bronchiolitis.

The Cochrane database of systematic reviews·2000

Same author

Updated bronchodilator analysis.

Archives of pediatrics & adolescent medicine·1999

Same author

Analysing potential harm in Australian general practice: an incident-monitoring study.

The Medical journal of Australia·1998

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Bronchodilators offer minor, short-term symptom relief for infants with bronchiolitis, but their clinical benefit must be balanced against potential costs and side effects.

Area of Science:

Pediatric Respiratory Medicine
Evidence-Based Medicine
Clinical Pharmacology

Background:

Bronchiolitis is a common, highly infectious lower respiratory tract infection in infants.
Bronchodilator use for bronchiolitis is prevalent in North America but not in the UK.

Purpose of the Study:

To evaluate the efficacy of bronchodilators in improving clinical outcomes for infants diagnosed with acute bronchiolitis.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials (RCTs).
Searched multiple databases including CENTRAL, DARE, MEDLINE, and EMBASE.
Included 22 RCTs involving 1428 infants, comparing bronchodilators (excluding epinephrine) with placebo.

Main Results:

Related Experiment Videos

Bronchodilators showed a statistically significant but modest improvement in clinical scores (SMD -0.48).
No significant improvement in oxygenation was observed (WMD -0.57).
Subgroup analyses indicated greater effects in outpatients, but no reduction in hospital admission rates or duration.

Conclusions:

Bronchodilators provide small, short-term clinical score improvements in infants with bronchiolitis.
The limited benefits should be considered alongside the costs and potential adverse effects.
Potential bias from including studies with recurrent wheezing populations was noted.