Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Piecing together a ciliome.

Peter N Inglis1, Keith A Boroevich, Michel R Leroux

  • 1Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, BC V5A 1S6, Canada.

Trends in Genetics : TIG
|July 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

scHDeepInsight: a hierarchical deep learning framework for precise immune cell annotation in single-cell RNA-seq data.

Briefings in bioinformatics·2025
Same author

Voltage-matrix nanopore profiling for the discrimination of protein mixtures.

Chemical science·2025
Same author

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies.

Clinical genetics·2025
Same author

VBayesMM: variational Bayesian neural network to prioritize important relationships of high-dimensional microbiome multiomics data.

Briefings in bioinformatics·2025
Same author

C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors.

Scientific reports·2024
Same author

Enhanced analysis of tabular data through Multi-representation DeepInsight.

Scientific reports·2024
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
Same journal

Rethinking molecular evolution through protein language model embeddings.

Trends in genetics : TIG·2026
Same journal

Co-transcriptional splicing: Distinct phases, mutual benefits, and basis for nuclear architecture.

Trends in genetics : TIG·2026
See all related articles

Cilia are essential cell organelles. This study compiles data to define the comprehensive ciliary proteome, or "ciliome," aiding research into ciliary disorders.

Area of Science:

  • Cell Biology
  • Genetics
  • Proteomics

Background:

  • Cilia are microtubule-based cell appendages involved in movement and sensing.
  • Ciliary disorders, like polycystic kidney disease, are linked to numerous genes.
  • Understanding cilia's protein composition is crucial for disease research.

Purpose of the Study:

  • To review and assess studies on ciliary protein makeup.
  • To define a comprehensive ciliary proteome, termed the 'ciliome'.
  • To compile a database of known and putative ciliary proteins.

Main Methods:

  • Bioinformatics analysis
  • Genomic data integration
  • Proteomic data assessment
  • Cross-organism data comparison

Related Experiment Videos

Main Results:

  • A comprehensive review of ciliary protein studies was conducted.
  • A database of known and putative ciliary proteins was compiled.
  • Identified proteins include RAB-like small GTPases and MIP-T3, potentially linked to ciliopathies.

Conclusions:

  • The compiled 'ciliome' provides a valuable resource for ciliary research.
  • Further investigation into identified proteins may elucidate mechanisms of ciliary disorders.
  • This work enhances understanding of ciliary protein function and disease association.