Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Methotrexate: improving safety profile.

Claire Grills¹, Susan Burge

¹Department Dermatology, Churchill Hospital, Oxford, UK. nandcgrills@optusnet.com.au

The Australasian Journal of Dermatology

|July 27, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of Multidisciplinary Consensus-Informed Guidance for the Management of Paediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Among Clinicians From Australasian Tertiary Referral Hospitals.

Journal of paediatrics and child health·2026

Same author

How Good Is the Australian Paediatric Baseline Series at Detecting Allergic Contact Dermatitis?

Contact dermatitis·2026

Same author

Concomitant management of alopecia universalis and ulcerative colitis with upadacitinib.

Internal medicine journal·2024

Same author

Solution using Stomahesive® wafers for allergic contact dermatitis caused by isobornyl acrylate in glucose monitoring sensors.

The Australasian journal of dermatology·2021

Same author

Consensus statement for the treatment of infantile haemangiomas with propranolol.

The Australasian journal of dermatology·2017

Same author

What Should General Practice Trainees Learn about Atopic Eczema?

Journal of clinical medicine·2015

Same journal

Revisiting the Role of Antibiotics in Hidradenitis Suppurativa in the Biologic Era.

The Australasian journal of dermatology·2026

Same journal

Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series.

The Australasian journal of dermatology·2026

Same journal

The Dermatologist's Role in Early PMOS Diagnosis.

The Australasian journal of dermatology·2026

Same journal

From Curriculum Variation to Clinical Capability: Advancing Dermatology Education in Australia.

The Australasian journal of dermatology·2026

Same journal

Fatal Phenobarbital-Associated Toxic Epidermal Necrolysis With Severe Acute Kidney Injury and Multiorgan Failure: Prognostic Value of SCORTEN and ALDEN.

The Australasian journal of dermatology·2026

Same journal

Granulomatous Vasculitis: An Unusual Manifestation of Metastatic Crohn's Disease.

The Australasian journal of dermatology·2026

See all related articles

Methotrexate prescribing has led to patient safety incidents. An audit revealed poor documentation and inconsistent monitoring, prompting the development of new evidence-based guidelines to minimize drug complications.

Area of Science:

Dermatology
Pharmacology
Patient Safety

Background:

Methotrexate is a common treatment for psoriasis.
Patient safety incidents linked to methotrexate prescribing are a growing concern globally.
Previous audits indicate issues with methotrexate prescribing practices.

Purpose of the Study:

To audit current methotrexate prescribing practices for psoriasis patients within the department.
To identify areas for improvement in patient information and monitoring.
To develop evidence-based guidelines to enhance patient safety.

Main Methods:

Retrospective audit of 49 psoriasis patients on methotrexate.
Review of departmental prescribing practices and documentation.
Literature review of current evidence and guidelines from leading centers.

Related Experiment Videos

Main Results:

Inadequate documentation regarding patient information on methotrexate complications.
Inconsistencies in prescribing practices, particularly concerning hematological monitoring.
Identification of procollagen peptide III as a useful marker for monitoring liver toxicity.

Conclusions:

Development of consistent, evidence-based guidelines is crucial for minimizing methotrexate complications.
Updated guidelines should incorporate newer monitoring methods like procollagen peptide III.
Further audits are recommended to ensure adherence to new guidelines and improve patient safety.