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Drug analysis by Raman and micro-Raman spectroscopy.
1Laboratoire de Spectroscopie Infrarouge et Raman, Université de Bordeaux I, 351 cours de la Libération, 33405 Talence, France.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1986
Summary
Raman spectroscopy techniques offer powerful methods for drug analysis, enabling qualitative and quantitative insights into drug structure, interactions, and reactivity across various drug classes.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Pharmaceutical Science
Background:
- Raman spectroscopy and its variants are valuable tools for chemical analysis.
- Understanding drug behavior requires detailed structural and interaction studies.
Purpose of the Study:
- To explore the application of Raman, resonance Raman, and micro-Raman spectroscopy in drug analysis.
- To elucidate the possibilities and limitations of these techniques for qualitative and quantitative drug assessment.
- To investigate drug reactivity through principal interaction modes.
Main Methods:
- Utilized Raman spectroscopy, resonance Raman spectroscopy, and micro-Raman spectroscopy.
- Analyzed drug structure, interactions, and reactivity.
- Examined principal interaction modes including hydrogen bonding, proton transfer, charge transfer, and ion-molecule attraction.
Main Results:
- Demonstrated the utility of Raman spectroscopy for drug analysis.
- Provided insights into the qualitative and quantitative capabilities of the techniques.
- Illustrated drug reactivity mechanisms using examples from various drug families.
Conclusions:
- Raman spectroscopy techniques are versatile for comprehensive drug investigation.
- The methods provide a basis for understanding drug reactivity and interactions.
- Applicable to diverse drug classes such as vitamins, antidepressants, and cardiovascular drugs.
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