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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Genetic algorithms for protein conformation sampling and optimization in a discrete backbone dihedral angle space.

Yuedong Yang1, Haiyan Liu

  • 1Hefei National Laboratory for Physical Sciences, Key Laboratory of Structural Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.

Journal of Computational Chemistry
|July 27, 2006
PubMed
Summary

This study introduces an efficient genetic algorithm for protein conformation sampling and optimization. The method highlights the importance of local minimization and population diversity for accurate protein structure prediction.

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