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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 14, 2026

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Identifying site-specific metastasis genes and functions.

G P Gupta1, A J Minn, Y Kang

  • 1Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Cold Spring Harbor Symposia on Quantitative Biology
|July 28, 2006
PubMed
Summary

Researchers identified genes promoting organ-specific metastasis in breast cancer. These genes enhance primary tumor growth and metastatic colonization, offering new insights into cancer progression and potential clinical applications.

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Last Updated: Jul 14, 2026

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Published on: August 24, 2010

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06:31

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Metastasis is a critical, life-threatening stage of cancer.
  • Understanding metastasis mechanisms is crucial for clinical relevance.
  • Organ-specific colonization patterns require comprehensive biological investigation.

Purpose of the Study:

  • To discover genes mediating organ-specific metastatic colonization in breast cancer.
  • To identify genes involved in early tumor progression and metastasis.
  • To explore the dual functions of metastasis-associated genes.

Main Methods:

  • Utilized a xenograft model of breast cancer metastasis.
  • Analyzed transcriptomic data from primary breast cancer cohorts.
  • Examined gene expression patterns and their correlation with metastatic propensity.

Main Results:

  • Identified a subset of site-specific metastasis genes selected early in tumor progression.
  • High expression of these genes predicts lung metastasis, independent of other prognostic markers.
  • These genes exhibit dual functions: enhancing primary tumorigenicity and metastatic activity.

Conclusions:

  • Discovered genes that drive organ-specific metastasis and early tumor progression.
  • These findings enhance understanding of metastatic cascades and gene expression interpretation.
  • Opened new avenues for clinical applications in cancer treatment and prognosis.