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Updated: Aug 6, 2026
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Orthotopic Left Lung Transplantation in Rats
Published on: July 3, 2025
Long-term outcome after pulmonary retransplantation
Martin Strueber1, Stefan Fischer, Jens Gottlieb
1Hannover Thoracic Transplant Program, Division of Thoracic- and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany. strueber@thg.mh-hannover.de
The Journal of Thoracic and Cardiovascular Surgery
|July 29, 2006
Summary
Redo lung transplantation for bronchiolitis obliterans syndrome offers good long-term survival, comparable to primary lung transplants. This procedure is a viable option for selected patients with end-stage BOS after lung transplant.
Area of Science:
- Cardiology and Thoracic Surgery
- Transplantation Medicine
Background:
- Bronchiolitis obliterans syndrome (BOS) is a major limitation for long-term lung transplant recipients.
- Redo lung transplantation is an option for end-stage BOS.
Purpose of the Study:
- To compare long-term outcomes of redo lung transplantation for BOS with primary lung transplantation.
- To evaluate outcomes for other redo transplant indications.
Main Methods:
- Retrospective analysis of 614 lung transplants, with 54 (8.5%) being redo procedures.
- Stratification of redo transplants by indication: BOS, acute graft failure, airway complications.
- Comparison of survival rates and BOS recurrence between primary and redo lung transplantation.
Main Results:
- Redo lung transplantation for BOS showed 1-year survival of 78% and 5-year survival of 62%, similar to primary transplants.
- Redo transplants for acute graft failure/airway complications had 1-year survival of 50%.
- BOS recurrence rates were similar after redo transplantation for BOS compared to primary transplantation.
Conclusions:
- Redo lung transplantation for end-stage BOS provides acceptable long-term outcomes in selected patients.
- Stratifying BOS from other redo transplant indications is crucial for future analyses due to differing mortality rates.
