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Updated: Aug 6, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
Published on: June 2, 2015
Ischemic preconditioning for the clinician
Shereif H Rezkalla1, Robert A Kloner
1Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin 54449, USA. rezkalla.shereif@marshfieldclinic.org
Abstract:
Ischemic preconditioning is a physiologic phenomenon that occurs in the cardiac muscle in which brief episodes of ischemia protect the heart when exposed to a sustained ischemia. Clinical counterparts include potential benefits of preinfarction angina and less ischemia after a second, compared to a first, coronary angioplasty balloon inflation. This article will discuss how preconditioning might be applied to the clinical setting during acute myocardial infarction, coronary interventions, and cardiac surgery.
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