Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits
Mamoru Tochigi1, Chieko Kato, Takeshi Otowa
1Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Abstract:
Corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of anxiety disorders and depression. Corticotropin-releasing hormone receptor 2 (CRHR2) is one of the receptors that mediate CRH signal. The purpose of the present study was to investigate the association between the CRHR2 gene and personality traits, evaluated using the Revised NEO Personality Inventory (NEO PI-R), in 243 healthy Japanese subjects. As a result, significant association was observed between the polymorphism in intron 2 (rs2267717) and Openness (P = 0.004, uncorrected, anova), while no relationship was observed concerning Neuroticism. The present result suggests an association between CRHR2 and the personality trait of Openness.
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Personality Theory by Eysenck and Eysenck
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
Cultural Influences on Personality
Introduction to Personality Psychology
Early Theories of Personality
The study of personality dates...
Cattell's 16 Personality Factors
In contrast, source traits are the fundamental,...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase


