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Updated: Aug 6, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
A child with anterior mediastinal mass supported with veno-arterial extracorporeal membrane oxygenation
Talya K E Frey1, Arun Chopra, Richard J Lin
1Department of Anesthesiology, Children's Hospital of Philadelphia, USA.
Insights
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) successfully rescued a child with an anterior mediastinal mass and cardiopulmonary collapse. Chemotherapy was safely administered during VA-ECMO support, demonstrating its feasibility.
Area of Science:
- Pediatric Critical Care Medicine
- Cardiopulmonary Support
- Oncology
Background:
- Anterior mediastinal masses can cause life-threatening cardiopulmonary compromise in children.
- Prompt diagnosis and management are crucial for patient survival.
Observation:
- A pediatric patient presented with an anterior mediastinal mass complicated by cardiopulmonary collapse.
- Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) was initiated for cardiopulmonary support.
Findings:
- VA-ECMO provided effective rescue and stabilization for the pediatric patient.
- Chemotherapy administration was feasible and successfully completed during VA-ECMO support.
- The patient experienced a successful outcome with resolution of cardiopulmonary compromise.
Implications:
- VA-ECMO is a viable rescue strategy for pediatric patients with anterior mediastinal masses and hemodynamic instability.
- Chemotherapy can be safely administered to pediatric patients on VA-ECMO, enabling timely oncologic treatment.
Objective:
To demonstrate the utility of rescue with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and to demonstrate the feasibility of administration of chemotherapy during VA-ECMO in a child with an anterior mediastinal mass.
Design:
Case report.
Setting:
Large, tertiary care, pediatric intensive care unit.
Patient:
One patient with cardiopulmonary collapse in the setting of a new diagnosis of an anterior mediastinal mass.
Interventions:
Cardiopulmonary support with VA-ECMO; administration of chemotherapy during VA-ECMO.
Measurements And Main Results:
Successful rescue with VA-ECMO and successful chemotherapy while on VA-ECMO.
Conclusions:
VA-ECMO can be successfully used to support patients with cardiopulmonary failure during initial diagnosis of an anterior mediastinal mass. In addition, we have demonstrated that successful chemotherapy can be administered while the patient is supported on VA-ECMO.
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