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Updated: Aug 6, 2026
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
[Extensive cutaneous candidiasis revealing cutaneous T-cell lymphoma: 2 cases]
T Duong1, S Ingen-Housz-Oro, A Gaulier
1Service de Dermatologie, Centre Hospitalier Victor Dupouy, Argenteuil.
Annales De Dermatologie Et De Venereologie
|August 4, 2006
Summary
Severe candidiasis can indicate underlying T-cell lymphoma. This study highlights two cases where extensive cutaneous candidiasis led to the diagnosis of cutaneous T-cell lymphoma (CTCL), emphasizing the importance of considering CTCL in such presentations.
Area of Science:
- Dermatology
- Oncology
- Infectious Diseases
Background:
- Severe candidiasis typically occurs in patients with immunodeficiency diseases.
- Blood dyscrasias are rarely identified as the initial presentation of diffuse candidiasis.
- Cutaneous T-cell lymphoma (CTCL) can manifest with extensive and atypical cutaneous candidiasis.
Observation:
- Two patients with CTCL presented with widespread, atypical cutaneous candidiasis.
- Both patients showed positive results for Candida albicans on skin scrapings.
- Histological examination revealed fungal elements and lymphocytic infiltrates consistent with mycosis fungoides.
Findings:
- Circulating Sezary cells in hyperleukocytosis prompted suspicion of underlying CTCL.
- Skin biopsies confirmed mycosis fungoides in both cases.
- CTCL may exacerbate candidiasis by compromising skin integrity and cell-mediated immunity.
Implications:
- Widespread cutaneous candidiasis can be an early indicator of CTCL.
- Early diagnosis and treatment of CTCL are crucial for patient outcomes.
- Understanding the interplay between CTCL and opportunistic infections like candidiasis is vital for patient management.
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