Related Experiment Video
Updated: Aug 18, 2026

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
Published on: February 7, 2012
[Expression of embryonal and differentiational proteins in chordomas and in the notochord]
C Tamayama1, M Miyauchi, K Maruyama
1Dept. of Pathology, Chiba Cancer Center Research Institute.
Abstract:
The expression of the embryonal and of the differentiational proteins in 12 cases of chordoma and in the notochord of a 4-month-old and a 5-month-old human embryo have been examined immunohistologically by the ABC method using polyclonal antibodies to CEA, AFP, or S-100, and the monoclonal antibody to cytokeratin. It was found that S-100 was expressed in all cases of chordoma and in the notochords examined. CEA and cytokeratin also were found expressed in some cases of chordoma but not in the notochords. These proteins were found expressed more strongly in chordomas without a metastasis than in those with a metastasis. In the metastatic lesions, these proteins were expressed more strongly than in the primary lesions. The antibody to AFP reacted with neither the chordomas nor the notochords tested. These results suggest a possible link between the gene-expression of the tumor cells and the microenvironment in which they are harbored.
More Related Videos
11:48Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
Published on: January 17, 2016
06:49Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
Published on: January 12, 2022
Related Concept Videos
Neurulation
Determination
Master Transcription Regulators
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Cellular Differentiation
A zygote is a...