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Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Paroxysmal kinesigenic dyskinesia
A T Alibhoy1, Subhashie Wijemanne, Ranjanie Gamage
1National Hospital of Sri Lanka, Colombo. atalibhoy@yahoo.uk
The Ceylon Medical Journal
|August 11, 2006
Summary
Paroxysmal kinesigenic dyskinesia (PKD), a rare movement disorder, was identified in Sri Lanka. This study details six male patients, showing symptoms and treatment responses consistent with global patterns.
Area of Science:
- Neurology
- Movement Disorders
Background:
- Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurological disorder.
- Characterized by sudden, involuntary movements triggered by action.
- Previously unreported in Sri Lanka.
Observation:
- Study included six male patients in Sri Lanka with PKD.
- Onset between 11-22 years.
- Dystonic movements, often facial, with speech difficulty during attacks.
Findings:
- Attacks were brief (10-60 seconds), frequent (up to 20/day).
- Sporadic cases with no secondary cause or family history.
- All patients responded well to anticonvulsant treatment.
Implications:
- This study describes the first reported cases of PKD in Sri Lanka.
- The clinical presentation and response to treatment align with international findings.
- Highlights the need for awareness and diagnosis of PKD in the region.
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