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Updated: Aug 6, 2026

Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling
Published on: August 1, 2016
Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling
Valentina Lissandron1, Manuela Zaccolo
1Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35100, Padova, Italy.
Abstract:
The sympathetic control over excitation-contraction coupling (ECC) is mediated by the cAMP/PKA signalling pathway. However, in the myocyte, the same signalling pathway is responsible for triggering a plethora of diverse intracellular functions the control of which must be independent of the regulation of ECC. Here we discuss what are the molecular mechanisms leading to selective modulation of ECC in cardiac myocytes with a particular focus on the role of spatial confinement of PKA subsets and the compartmentalization of cAMP.
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