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Substance P immunoreactivity in Alzheimer disease: a study in cases presenting symmetric or asymmetric cortical
C Bouras1, P G Vallet, P R Hof
1Département de Psychiatrie, Institutions Universitaires de Psychiatrie, Geneva, Switzerland.
Alzheimer Disease and Associated Disorders
|January 1, 1990
Abstract:
Substance P-like immunoreactivity was visualized by immunohistochemical methods in 20 postmortem brains: 6 senile, 4 presenile Alzheimer dementia (AD), 3 AD with interhemispheric asymmetric cortical atrophy, and 7 control cases. For all pathological cases, the SP-like immunoreactivity was significantly reduced in the neocortical areas and in the hippocampus. This contrasted with an enhanced SP-like immunoreactivity in the pallidum and the substantia nigra in AD brains and a more pronounced SP-like immunoreactivity in the more atrophic side in the asymmetrically atrophied brains.