Sulphate and osteoarthritis: decrease of serum sulphate levels by an additional 3-h fast and a 3-h glucose tolerance
C M Blinn1, B A Biggee, T E McAlindon
1Connective Tissue Research Laboratory, Edith Nourse Rogers Memorial Veterans Hospital, MA 01730, USA.
Annals of the Rheumatic Diseases
|August 15, 2006
Summary
Fasting or consuming glucose significantly lowers serum sulphate levels, potentially impacting cartilage health and contributing to osteoarthritis. This study quantifies these reductions over a three-hour period.
Area of Science:
- Biochemistry
- Metabolic Research
- Osteoarthritis Pathophysiology
Background:
- Low serum sulphate levels may be linked to osteoarthritis development.
- This reduction is potentially due to decreased cartilage chondroitin sulphation.
Purpose of the Study:
- To quantify serum sulphate level changes during fasting or glucose intake.
- To determine the extent of sulphate reduction within a three-hour post-absorptive period.
Main Methods:
- Serum samples were collected from 14 osteoarthritis patients over three hours.
- Measurements were taken during continued fasting and after glucose ingestion.
- Sulphate and glucose levels were analyzed using high-performance liquid chromatography.
Main Results:
- Continued fasting for three hours caused a mean serum sulphate decrease of 9.3%.
- Ingesting 75g of glucose resulted in a more significant mean sulphate reduction of 18.9%.
- Individual sulphate level drops ranged from 3-20% with fasting and 10-33% with glucose.
Conclusions:
- A three-hour fast markedly reduces serum sulphate levels.
- Glucose ingestion (without protein) doubled the sulphate reduction observed during fasting.
- These findings suggest fasting and protein-free calories may lead to chondroitin undersulphation, potentially affecting osteoarthritis.
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