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[The role of oxidative stress in pathogenesis of obesity]

M D Sikharulidze, N G Dzhanashiia, T V Sanikidze

    Georgian Medical News
    |August 15, 2006
    PubMed

    Insights

    White adipose tissue plays a key role in obesity-induced oxidative stress. Citrus intake can help normalize fat metabolism, reduce oxidative stress, and restore adipocyte function.

    Area of Science:

    • Biochemistry
    • Metabolic Disorders
    • Nutritional Science

    Context:

    • White adipose tissue is a potential therapeutic target for obesity.
    • Diet-Inducible Obesity (DIO) in rats is a relevant model for studying metabolic dysfunction.
    • Oxidative stress is implicated in the pathogenesis of obesity.

    Purpose:

    • To investigate the characteristics of oxidative metabolism in adipose tissue during diet-inducible obesity (DIO).
    • To evaluate the effects of citrus on adipose tissue metabolism and oxidative stress in DIO rats.

    Summary:

    • Obesity in the DIO rat model is characterized by mitochondrial electron transport chain dysfunction, increased reactive oxygen species (ROS) and lipoperoxide generation, superoxide dismutase inactivation, and heightened lipid peroxidation, leading to oxidative stress in adipose tissue.
    • Citrus consumption was found to normalize body lipid metabolism, which in turn restored mitochondrial electron transport, decreased oxidative stress, and improved adipocyte metabolism.

    Impact:

    • These findings highlight the critical role of adipose tissue in obesity-related oxidative stress.
    • Citrus fruits show potential therapeutic benefits in managing obesity by targeting fat metabolism and mitigating oxidative damage.
    • Understanding these mechanisms can inform the development of novel anti-obesity drugs focusing on white adipose tissue.

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