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Related Experiment Videos

Prevention of chemically induced synaptosomal changes.

S C Bondy1, M McKee

  • 1Southern Occupational Health Center, University of California, Irvine 92717.

Journal of Neuroscience Research
|February 1, 1990
PubMed
Summary

Environmental toxins like methyl mercury and chlordecone alter synaptosome function, increasing permeability and affecting calcium levels. Antioxidants and gangliosides may offer protection against these harmful effects.

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Area of Science:

  • Neuroscience
  • Environmental Toxicology

Background:

  • Synaptosomes are crucial for neuronal function.
  • Environmental toxins can disrupt cellular processes.

Purpose of the Study:

  • To investigate how environmental toxins affect synaptosome properties.
  • To examine the protective effects of ganglioside GM1 and alpha-tocopherol.

Main Methods:

  • Incubation of synaptosomes with methyl mercury, chlordecone, calcium-depleted medium, or oxidative agents.
  • Measurement of intracellular calcium ([Ca2+]i), calcium uptake, membrane permeability, and lipid peroxidation.
  • Assessment of protective effects of ganglioside GM1 and alpha-tocopherol.

Main Results:

  • Adverse conditions altered [Ca2+]i and increased synaptosome permeability.

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  • All tested adverse conditions led to increased membrane permeability.
  • Ganglioside GM1 and alpha-tocopherol demonstrated partial or complete protection.

    • Conclusions:

    • Environmental toxins significantly impair synaptosome function.
    • Protecting synaptosome integrity is vital for neuronal health.
    • Gangliosides and antioxidants show potential in mitigating toxin-induced damage.