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[Plasma releasing factors in common migraine]
A Pradalier1, J M Launay, N Cauet
1Service de Médecine interne, Hôpital Rothschild, Paris.
Presse Medicale (Paris, France : 1983)
|March 24, 1990
Summary
Migraine patients
Area of Science:
- Neuroscience
- Hematology
Background:
- Platelet abnormalities in migraine are considered secondary.
- The role of plasma bioamine-releasing factors in migraine is not well understood.
Purpose of the Study:
- To investigate the presence of bioamine-releasing factors in the plasma of patients with common migraine.
- To characterize these factors and their potential role in migraine pathophysiology.
Main Methods:
- Collected blood samples from migraine patients during and between attacks, and from healthy controls.
- Performed release experiments using patient plasma and control blood/platelets.
- Measured bioamine levels, serotonin uptake, and serotonin release.
Main Results:
- Identified two plasma bioamine-releasing factors in migraineurs.
- A histamine-releasing factor was present both during and between attacks.
- A catecholamine and serotonin releasing factor was present only during attacks and was thermolabile with a molecular weight < 16 kDa.
Conclusions:
- Migraine plasma contains distinct bioamine-releasing factors.
- These factors may contribute to migraine pathophysiology, with different factors active during and between attacks.