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Related Experiment Videos

Scurvy: a disease almost forgotten.

Jesse M Olmedo1, James A Yiannias, Elizabeth B Windgassen

  • 1Department of Dermatology, Division of Regional and International Medicine, Mayo Clinic, Scottsdale, Arizona 85259, USA.

International Journal of Dermatology
|August 17, 2006
PubMed
Summary
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Scurvy, a vitamin C deficiency, can present with nonspecific symptoms and is often linked to other nutritional deficits. Early diagnosis and vitamin C supplementation are key for symptom resolution.

Area of Science:

  • Nutritional Science
  • Internal Medicine
  • Clinical Pathology

Background:

  • Scurvy, though less common, persists in industrialized nations.
  • Recent large-scale studies on scurvy pathogenesis, signs, and symptoms are limited.

Observation:

  • A retrospective review identified 12 patients with scurvy between 1976-2002.
  • Associated factors included gastrointestinal disease, poor dentition, food faddism, and alcoholism.
  • Concomitant vitamin or mineral deficiencies were common.

Findings:

  • Common symptoms included bruising, arthralgias, and joint swelling.
  • Pedal edema, bruising, and mucosal changes were frequent signs.
  • Five of six patients treated with vitamin C showed complete symptom resolution.

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Implications:

  • Scurvy presentation can range from classic to nonspecific symptoms.
  • Consider thorough dietary history and serum ascorbic acid testing for suspected cases.
  • Prompt vitamin C supplementation is crucial for effective treatment and symptom resolution.