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Updated: Jul 20, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Anti-microbial resistance in intensive care units in Bogotá, Colombia, 2001-2003]
Carlos Alvarez1, Jorge Cortes, Alvaro Arango
1Unidad de Infectología, Hospital Universitario San Ignacio, Facultad de Medicina, Universidad Nacional de Colombia. caalvarezmo@unal.edu.co
Objectives:
Determining the frequency of antimicrobial resistance amongst bacterial isolates obtained from patients in Intensive Care Units (ICU).
Methods:
Study data relating to 2001 to 2003 regarding microbiological isolates was obtained from a laboratory network for the ICUs of 14 third-level hospitals in Bogotá belonging to the Bogotá Bacterial Resistance Control Group (BBRCG). 27,301 isolates were obtained and their susceptibility profiles were analysed using WHONET 5.3.
Results:
Staphylococcus aureus, Escherichia coli, coagulase negative Staphylococci (CNS), Pseudomonas aeruginosa y Klebsiella pneumoniae were the most commonly found microorganisms. Oxacillin-resistance rate ranged from 61% at 63% during 2001 to 2003 amongst S. aureus isolates and 78% to 83% amongst coagulase negative Staphylococci (CNS). E. coli resistance to third generation cephalosporines was found to be about 10% and over 20% to ciprofloxacin. K. pneumoniae isolates' resistance to third-generation cephalosporines was found to be more than 30% in 2001. P. aeruginosa resistance to all but a few antibiotics was found to be over 30% and multirresistance frequency was found to be 16% to 24%.
Conclusion:
The antimicrobial resistance rates found in the ICU of hospitals in Bogotá were higher than those reported in surveillance studies in the USA, Europe or other Latin-American cities.
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