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Related Experiment Videos

[Late paternity: spermatogenetic aspects].

M Dakouane-Giudicelli1, M Bergère, M Albert

  • 1Unité de pathologie cellulaire et génétique, UPRES EA 2493, faculté de médecine Paris-Ile-de-France Ouest, université de Versailles-Saint-Quentin, centre hospitalier de Poissy-Saint-Germain-en-Laye, 78303 Poissy cedex, France. dakouane@hotmail.com

Gynecologie, Obstetrique & Fertilite
|August 26, 2006
PubMed
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Paternal age affects sperm quality and can increase genetic risks. While some studies show no difference in aneuploidy for men with preserved spermatogenesis, others indicate increased risks when sperm production stops.

Area of Science:

  • Reproductive biology
  • Human genetics
  • Andrology

Context:

  • Maternal age's impact on meiotic abnormality is known, but paternal age effects are less understood.
  • Assisted Reproduction Techniques (ART) are increasingly used by older men, raising concerns about paternal age risks.
  • This review synthesizes current knowledge on age-related changes in male reproductive health.

Purpose:

  • To review the impact of paternal age on male semen parameters, testicular histology, and genetic risks.
  • To analyze age-related alterations in sperm motility, vitality, morphology, and semen volume.
  • To investigate the relationship between paternal age, spermatogenesis, and chromosomal aneuploidy.

Summary:

  • Sperm motility, vitality, morphology, and semen volume decline with increasing paternal age.

Related Experiment Videos

  • Testis histology shows age-related changes, including basal membrane thickening and decreased germinal and Sertoli cell counts.
  • While some studies show controversial results on aneuploidy, this review found increased postmeiotic aneuploidy when spermiogenesis had stopped in older men.
  • Epidemiological studies link paternal age to autosomal dominant diseases, but direct sperm DNA analysis for specific conditions like achondroplasia and Apert syndrome did not show increased mutation frequency.

    • Impact:

    • Highlights the importance of considering paternal age in reproductive health assessments.
    • Provides insights into age-related male infertility and potential genetic risks for offspring.
    • Informs clinical practice regarding ART for older men and genetic counseling.