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Updated: Jul 20, 2026
07:47
The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
Published on: November 13, 2013
[Dissertations 25 years after date 9. How is tooth eruption regulated?]
1Afdeling Orthodontie en Orale Biologie van het Universitair Medisch Centrum Sint Radboud, Nijmegen. j.maltha@dent.umcn.nl
Nederlands Tijdschrift Voor Tandheelkunde
|August 29, 2006
Summary
Tooth eruption is controlled by the reduced enamel epithelium and dental follicle, not the periodontal ligament. Research in beagles shows the ligament develops late, playing no role in initiating tooth movement.
Area of Science:
- Developmental biology
- Craniofacial development
- Odontology
Context:
- Investigates the mechanisms of tooth eruption, challenging historical theories.
- Utilizes beagle models, which have limited eruption similar to humans, unlike rodents.
- Builds upon 25 years of research into canine tooth eruption.
Purpose:
- To elucidate the primary driving forces and regulatory mechanisms of tooth eruption.
- To re-evaluate the role of the periodontal ligament in the eruption process.
- To establish the current understanding of tooth eruption based on canine models.
Summary:
- The reduced enamel epithelium and dental follicle regulate bone remodeling, guiding erupting teeth.
- The periodontal ligament develops post-eruption and is not a primary factor in initiating tooth movement.
- The tooth itself is not involved in regulating its own eruption sequence.
Impact:
- Revises the understanding of tooth eruption mechanisms, shifting focus from the periodontal ligament.
- Provides a more accurate model for studying human tooth eruption.
- Informs future research on dental development and potential eruption disorders.
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