Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cells in surgically resected appendices.

Vijaya V Mysorekar1, Sudakshina Chanda, Chitralekha P Dandeka

  • 1Department of Pathology, M.S. Ramaiah Medical College, Bangalore.

Indian Journal of Pathology & Microbiology
|August 29, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling Complexity: Delving into a Novel Pigmented Epithelioid Melanocytoma Case.

Indian dermatology online journal·2024
Same author

Wunderlich Syndrome: A Rare Case Associated with Bleeding Renal Angiomyolipoma (AML).

Indian journal of nephrology·2024
Same author

Resveratrol, cancer and cancer stem cells: A review on past to future.

Current research in food science·2020
Same author

Aberrant signal transduction in Indian triple-negative breast cancer patients.

Journal of cancer research and therapeutics·2019
Same author

Sentinel Lymph Node Biopsy in Breast Cancer.

World journal of oncology·2017
Same author

Hepatic angiosarcoma developing in an infantile hemangioendothelioma: A rare case report.

Journal of cancer research and therapeutics·2016
Same journal

Prof Aseem Kumar Basu, MBBS, DTM and H, FRCPath (Lond), PhD (Lond), Fmr. Professor Department of Haematology, School of Tropical Medicine, Kolkata, India.

Indian journal of pathology & microbiology·2026
Same journal

Beyond the ordinary: Extramedullary hematopoiesis in an ossified psammomatous meningioma.

Indian journal of pathology & microbiology·2026
Same journal

Histomorphological spectrum of Adnexal Tumor with rippled pattern an unusual variant: Report of three cases.

Indian journal of pathology & microbiology·2026
Same journal

The shape-shifter: A case of pleomorphic giant cell carcinoma of prostate.

Indian journal of pathology & microbiology·2026
Same journal

Metachronous renal cell carcinoma with delayed testicular metastasis coexisting with synchronous prostatic adenocarcinoma.

Indian journal of pathology & microbiology·2026
Same journal

Cribriform-morular thyroid carcinoma with nodal metastasis: A diagnostic dilemma.

Indian journal of pathology & microbiology·2026
See all related articles

Mast cells play a significant role in appendicitis, with their counts increasing in acute and chronic inflammation. This suggests mast cell mediators may trigger appendicitis, independent of obstruction.

Area of Science:

  • Immunology
  • Gastroenterology
  • Pathology

Background:

  • Mast cells are recognized effector cells in inflammatory conditions.
  • The specific role of mast cells in the pathogenesis of appendicitis remains largely uncharacterized.

Purpose of the Study:

  • To investigate the involvement and density of mast cells in normal, acute, and chronic appendicitis.
  • To evaluate the potential role of mast cells as a triggering factor in appendicitis.

Main Methods:

  • Histological examination of 150 appendix samples (normal and inflamed).
  • Quantification of neutrophil, lymphocyte, and eosinophil infiltration.
  • Mast cell counting in toluidine blue-stained sections.

Main Results:

Related Experiment Videos

  • Eosinophil counts were significantly lower in normal and chronic appendicitis compared to acute appendicitis.
  • Mast cell counts were lowest in normal appendices, significantly higher in acute appendicitis, and highest in chronic appendicitis.
  • Appendiceal obstruction (faecoliths, parasites) was identified in only a minority of inflamed cases.

Conclusions:

  • Mast cell involvement is significantly elevated in appendicitis, particularly in chronic forms.
  • The findings suggest a potential role for Type I hypersensitivity reactions mediated by mast cells in appendicitis pathogenesis.
  • Mast cell activation may represent an alternative or additional trigger for appendicitis, beyond mechanical obstruction.