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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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[Structural and functional analyses of MRS (major repeated sequnece) in Candida albicans. Application for genotyping
Hiroji Chibana1, Yuzuru Mikami
1Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan. chibana@faculty.chiba-u-jp
Abstract:
There are several different types of repeated sequences in the genome of Candida albicans, including the MRS (Major repeated sequence). In 2004, the whole genome sequence of C. albicans was published. Assembly of the sequences to chromosomal length contigs was not achieved, mainly due to interruption of the sequences by MRS. However, MRS including Ca3, 27A and RPS have been playing important roles in a number of epidemiological studies and basic biological investigations into C. albicans chromosome loss events and associated phenotypic changes. Here we summarize structural analyses from subrepeat sequences to the chromosome level, and functional analyses of MRS.
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