Related Experiment Video
Updated: Jul 20, 2026
08:34
Isolation of Atrial Myocytes from Adult Mice
Published on: July 25, 2019
B-type natriuretic peptide and weaning from mechanical ventilation
Armand Mekontso-Dessap1, Nicolas de Prost, Emmanuelle Girou
1Assistance Publique-Hôpitaux de Paris, Université Paris XII, Medical Intensive Care Unit, Centre Hospitalo-Universitaire Henri Mondor, 51, avenue du Mal de Lattre de Tassigny, 94010 Créteil Cedex, France. armand.dessap@creteil.inserm.fr
Intensive Care Medicine
|August 31, 2006
Summary
High B-type natriuretic peptide (BNP) levels before weaning indicate a higher risk of failure. BNP levels correlate with the duration of weaning and may decrease after successful treatment, aiding in extubation success.
Area of Science:
- Critical Care Medicine
- Cardiology
- Pulmonary Medicine
Background:
- Cardiac function and volume status are crucial in mechanical ventilation weaning.
- B-type natriuretic peptide (BNP) is a key biomarker for cardiac dysfunction.
Purpose of the Study:
- To evaluate the predictive value of BNP in the mechanical ventilation weaning process.
- To determine the correlation between BNP levels and weaning success or failure.
Main Methods:
- 102 patients ready for a 1-hour weaning trial were prospectively studied.
- Plasma BNP was measured before the trial and, for some, after.
- Weaning success was defined as sustained spontaneous breathing for >48 hours post-extubation.
Main Results:
- 41.2% of patients failed the weaning process.
- Elevated baseline BNP levels and airway pressure-breathing frequency product were independent risk factors for weaning failure.
- BNP levels decreased in patients who succeeded in weaning after diuretic therapy.
Conclusions:
- Baseline plasma BNP levels are higher in patients who experience weaning failure.
- Pre-weaning BNP levels correlate significantly with the duration of mechanical ventilation.
Related Concept Videos
01:23Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Noninvasive Positive-Pressure Ventilation (NIPPV)
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
01:29Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
01:17Hormonal Regulation of Blood Pressure
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...