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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Obstructive sleep apnoea among HIV patients.
V Lo Re1, S Schutte-Rodin, J R Kostman
1Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. vincent.lore@uphs.upenn.edu
International Journal of STD & AIDS
|September 1, 2006
Summary
Antiretroviral therapy can cause weight gain and lipodystrophy, increasing obstructive sleep apnoea (OSA) risk in HIV patients. Overweight, obesity, and lipodystrophy are key risk factors for OSA in this population.
Area of Science:
- Medical research
- Sleep medicine
- Infectious disease
Background:
- Antiretroviral therapy (ART) for HIV can cause body weight gain and lipodystrophy.
- These metabolic changes may contribute to sleep disturbances, including obstructive sleep apnoea (OSA).
Purpose of the Study:
- To investigate the prevalence and risk factors of OSA in HIV-infected patients.
- To identify clinical characteristics associated with OSA in this cohort.
Main Methods:
- Retrospective review of medical records of HIV-infected subjects diagnosed with OSA via polysomnography.
- Data collected between January 1, 2003, and December 31, 2004.
- Inclusion criteria: confirmed OSA (apnoea/hypopnoea index >= 5).
Main Results:
- Twelve HIV-infected subjects with confirmed OSA were identified.
- Common symptoms included daytime somnolence, fatigue, and snoring.
- High prevalence of overweight/obesity (92%), lipodystrophy (58%), and large neck circumference (>= 40 cm, 92%).
Conclusions:
- Overweight/obesity, lipodystrophy, and increased neck circumference are potential risk factors for OSA in HIV patients.
- Clinicians should screen HIV patients with these characteristics for OSA symptoms.
- Overnight polysomnography is crucial for diagnosing sleep disturbances like OSA in this population.
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